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Anzupgo is a steroid-free cream used to treat moderate to severe chronic hand eczema in adults. ANZUPGO is not indicated for use in RA. ANZUPGO is indicated for the topical treatment of moderate to severe chronic hand eczema (CHE) in adults who have had an inadequate response to, or for whom topical corticosteroids are not advisable.

Serious and sometimes fatal infections have been reported in patients receiving oral or topical JAK inhibitors. Avoid vaccination with live vaccines immediately prior to, during, and immediately after ANZUPGO treatment. If signs of reactivation occur, consult a hepatitis specialist.

Do not resume ANZUPGO until the infection resolves or is adequately treated. ANZUPGO ® (delgocitinib) cream is currently FDA-approved in the U.S. as the first and only topical pan-JAK treatment for chronic hand eczema (CHE). Consider viral hepatitis screening and monitoring for reactivation in accordance with clinical guidelines before starting therapy and during therapy with ANZUPGO.

Viral reactivation, including cases of herpes virus reactivation e. Advise patients to avoid sunlamps and minimize exposure to sunlight by wearing sun-protective clothing or using broad-spectrum sunscreen. The exact mechanism of action of delgocitinib in the treatment of moderate-to-severe CHE is currently not known.

It is not known whether ANZUPGO may be associated with the observed or potential adverse reactions of JAK inhibition. ANZUPGO is a prescription medicine used on the skin (topical) to treat moderate to severe chronic hand eczema in adults who are not well-controlled with, or cannot use topical corticosteroids.

Periodic skin examinations of the application sites are recommended for all patients, particularly those with risk factors for skin cancer.

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Anzupgo helps reduce inflammation and relieve symptoms such as redness, itching, and skin thickening. Closely monitor patients for the development of signs and symptoms of infection during and after treatment with ANZUPGO. Interrupt treatment with ANZUPGO if a patient develops a serious infection.

Avoid use of ANZUPGO in patients with an active or serious infection. ANZUPGO may increase the risk of infections.

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Prior to ANZUPGO treatment, complete all age-appropriate vaccinations as recommended by current immunization guidelines, including herpes zoster vaccinations. Anzupgo (Delgocitinib Cream) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources.

Eczema herpeticum was observed in a subject treated with ANZUPGO. If a patient develops herpes zoster, consider interrupting ANZUPGO treatment until the episode resolves. In a large, randomized, postmarketing safety trial of an oral JAK inhibitor in combination with methotrexate in rheumatoid arthritis RApatients 50 years of age and older with at least one cardiovascular risk factor, higher rates of all-cause mortality, including sudden cardiovascular death, major adverse cardiovascular events MACEoverall thrombosis, deep venous thrombosis DVTpulmonary embolism PEand malignancies excluding non-melanoma skin cancer were observed in patients treated with the JAK inhibitor compared to those treated with TNF blockers.

Anzupgo delgocitinib Uses Side

ANZUPGO is not recommended for use in patients with active hepatitis B or hepatitis C. Non-melanoma skin cancers, including basal cell carcinoma, have been reported in subjects treated with ANZUPGO. Limitations of Use : Use of ANZUPGO in combination with other JAK inhibitors or potent immunosuppressants is not recommended.

ANZUPGO is indicated for the topical treatment of moderate to severe chronic hand eczema CHE in adults who have had an inadequate response to, or for whom topical corticosteroids are not advisable. Consider the risks and benefits of treatment prior to initiating ANZUPGO in patients with chronic or recurrent infection, who have been exposed to tuberculosis, with a history of a serious or an opportunistic infection, or with underlying conditions that may predispose them to infection.

The impact of ANZUPGO on chronic viral hepatitis reactivation is unknown. Please see full Prescribing Information and Medication Guide. The first and only treatment for adults with moderate-to-severe Chronic Hand Eczema CHE 1,2.